After a year of quarantine restrictions, scientists around the world have wondered about one secret - creating the safest and simplest vaccine against the Covid-19 coronavirus.
Nizhny Novgorod scientists make a breakthrough vaccine against coronavirus Covid-19
How Covid-19 nose drops work?
Actually, this is a big project, and a number of vaccines are currently being developed to prevent viral infections. Work on this started two years ago, when we started developing a vaccine against norovirus and rotavirus infections. It is based on a molecular platform based on virus-like particles.
Virus-like particle based platform - What is it?
Molecules, which are artificially assembled from recombinant proteins, genetically engineered. They reproduce viral proteins and have the ability to form virus-like structures. It turns out a non-infectious virus particle. It does not contain an infectious agent, but its structure fully corresponds to a natural virus. Replicating structure, the immune system recognizes this artificial virus. AND, confusing it with the truth, produces antibodies.
Basically this formula works for most viral infectious diseases. therefore, when the coronavirus pandemic began a year ago, scientists from Nizhny Novgorod immediately began to adapt their developments to new challenges.
They took "chimeras" as a prototype - these are hybrid proteins, including components of two different viruses. Such chimeras must be assembled into virus-like particles with a double effect.. They can be used to vaccinate against two infections at the same time. for example, norovirus and coronavirus. The inner part of the virus-like particle consists of the base of the norovirus, and the outer part is coronavirus. This is a completely unique method..
Unlike existing analogues, this vaccine is suitable for both children, and for the elderly. However, this is not the only difference between the Nizhny Novgorod version of the vaccine.. This prototype will be much simpler than current injection.
We are planning to create a vaccine for mucous membranes, which can be administered by applying to mucous surfaces. for example, respiratory system or oral cavity. In other words, these are ordinary nose drops.
This is the perfect shape, allows the active ingredients of the vaccine to enter the body through mucous surfaces and produce antibodies. The developing immune response will be adequate to the route of penetration of the virus - through the respiratory system.
Contraindications for nose drops from Covid-19
As conceived by the creators of the vaccine, everyone can use it - children, adults and seniors. true, it's too early to talk about the presence of contraindications.
The vaccine is currently at the stage of laboratory and experimental research.. To move to the preclinical and clinical research phase, we need an investor. Now we are looking for an investor - first of all, it could be a pharmaceutical company. If there is such an investor, we will be able to start production next year.
Still 10 years ago, vaccine prototypes were developed at the Biotechnological Center in St. Petersburg and the Research Center "Vector". They even passed the first phase of clinical trials., but then the funding stopped.
Then it was concluded, that HIV infection can be stopped by treating HIV infection. But in the past five years, the infection rate of the population is approaching the point, when they start talking about an epidemic. Therefore, we are now planning to combine our efforts with these institutions and create one version of the vaccine.
Universal vaccine against Covid-19 and HIV
A little understanding of the above material, then we think that Russian scientists are at the peak of a breakthrough in the field of medicine. Indeed, in the plan to eradicate two diseases at once, it's like a worldwide pandemic of coronavirus infection Covid-19 and not a little-known Human Immunodeficiency Virus (HIV).
From our point of view, it looks more like an evolutionary push. After all, it is unlikely, without the current situation on earth, someone is thinking in the near future, on improving and eradicating HIV, at least at this rate.
Thank you for attention, understanding, and glory to the scientists and doctors of the Russian Federation! Keep it up, well done!
- We also recommend reading the article, as in China on packages of poultry meat from the Russian Federation revealed the Covid-19 genome
- The article was taken and published from open media sources
with text kp support.